Intranasal wnt3a Attenuates Neuronal Apoptosis through Frz1/PIWIL1a/FOXM1 Pathway in MCAO Rats.

@article{Matei2018IntranasalWA,
  title={Intranasal wnt3a Attenuates Neuronal Apoptosis through Frz1/PIWIL1a/FOXM1 Pathway in MCAO Rats.},
  author={Nathanael Matei and Justin Camara and Devin W McBride and Richard Camara and Ningbo Xu and Jiping Tang and John H Zhang},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2018},
  volume={38 30},
  pages={
          6787-6801
        }
}
After ischemic stroke, apoptosis of neurons is a primary factor in determining outcome. Wnt3a is a naturally occurring protein that has been shown to have protective effects in the brain for traumatic brain injury. Although wnt3a has been investigated in the phenomena of neurogenesis, anti-apoptosis, and anti-inflammation, it has never been investigated as a therapy for stroke. We hypothesized that the potential neuroprotective agent wnt3a would reduce infarction and improve behavior following… CONTINUE READING
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