Intranasal sumatriptan: in adolescents with migraine.

  title={Intranasal sumatriptan: in adolescents with migraine.},
  author={Monique P. Curran and Hannah C. Evans and Antona J. Wagstaff},
  journal={CNS drugs},
  volume={19 4},
  pages={335-43; discussion 345-6}
Sumatriptan, a serotonin 5-HT(1B/1D) agonist, constricts cranial blood vessels and inhibits neuroinflammatory processes. A single dose of sumatriptan 10 mg (approved European dosage) was significantly more effective than placebo in achieving headache relief at 1 hour post-dose in a well designed study. Headache relief occurred in significantly more adolescents administered a single dose of intranasal sumatriptan 20 mg (at 1 and 2 hours) and 5 mg (at 2 hours) than placebo (pooled data from two… CONTINUE READING