Intranasal sensitization with Blomia tropicalis antigens induces allergic responses in mice characterized by elevated antigen-specific and non-specific serum IgE and peripheral blood eosinophil counts.

@article{Takeda2004IntranasalSW,
  title={Intranasal sensitization with Blomia tropicalis antigens induces allergic responses in mice characterized by elevated antigen-specific and non-specific serum IgE and peripheral blood eosinophil counts.},
  author={Fumiko Takeda and Takeshi Arakawa and Hiromu Toma and Akira Ishii and Yoshiya Sato},
  journal={Revista do Instituto de Medicina Tropical de Sao Paulo},
  year={2004},
  volume={46 1},
  pages={1-8}
}
In order to evaluate the potential allergenicity of Blomia tropicalis (Bt) antigen, IgE production of both specific and non-specific for Bt antigen was monitored in BALB/c mice after exposure to the antigen by nasal route. It was evidenced that B. tropicalis contains a functional allergen in its components. The allergenic components, however, when administered intranasally without any adjuvant, did not function to induce IgE response within a short period. On the other hand, intranasal… CONTINUE READING