Intranasal oxytocin administration is reflected in human saliva

@article{Weisman2012IntranasalOA,
  title={Intranasal oxytocin administration is reflected in human saliva},
  author={O. Weisman and O. Zagoory-Sharon and R. Feldman},
  journal={Psychoneuroendocrinology},
  year={2012},
  volume={37},
  pages={1582-1586}
}
Following the discovery that intranasal administration of neuropeptides can reach the central nervous system, a growing number of studies applied intranasal oxytocin (OT) paradigms to demonstrate the positive effects of OT on social and emotional processes. The three-step paradigm typically included: OT administration, a 45-min waiting period, and approximately 1-h period of active drug effects when experimental manipulations are applied. Yet, this schedule has not been put to systematic… Expand
Salivary vasopressin increases following intranasal oxytocin administration
TLDR
Findings suggest a potential crosstalk between OT and AVP and indicate that baseline levels of the two neuropeptides may shape the degree to which these systems respond to exogenous manipulation. Expand
Salivary Oxytocin Concentrations in Males following Intranasal Administration of Oxytocin: A Double-Blind, Cross-Over Study
TLDR
The results are consistent with previous research in suggesting that salivary OT is a valid matrix for OT measurement and suggest that the post-administration ‘wait-time’ prior to starting experimental tasks could be reduced to 30 minutes, from the 45 minutes typically used, thereby enabling testing during peak OT concentrations. Expand
Increased Serum and Urinary Oxytocin Concentrations after Nasal Administration in Beagle Dogs
TLDR
The results confirm that intranasally administered oxytocin passes into the blood stream and the peak values are also similar in both the serum and the urinary Oxytocin concentration measurements, although there are large individual differences. Expand
Intranasal administration of oxytocin: Behavioral and clinical effects, a review
TLDR
It is concluded that IN-OT administration may be a promising approach to influence human communication but that the existing lack of information about the neural and physiological mechanisms involved is a serious problem for the proper understanding and interpretation of the observed effects. Expand
Oxytocin administration affects the production of multiple hormones
TLDR
It is suggested that research investigating OT effects should consider a possible cross-talk or interplay between the OT system and other hormones in the interpretation of the findings, and that OT effects may vary according to receptor distributions in key brain areas and thus, specific brain networks may shape the effects of OTadministration on the individual’s behavior. Expand
Elevated Salivary Levels of Oxytocin Persist More than 7 h after Intranasal Administration
TLDR
The increase of oxytocin levels for at least 7 h shows how effective intranasal administration of oxycoetocin is, and may raise ethical questions about potentially persisting behavioral effects after participants have left the lab setting. Expand
Measuring peripheral oxytocin and vasopressin in nonhuman primates
  • T. Ziegler
  • Medicine
  • American journal of primatology
  • 2018
TLDR
This review elucidates the challenges of OT measurement and the solutions that provide valuable data on OT's role in social behavior and makes suggestions based on empirical evidence for how to correctly preserve samples and emphasizes the need to validate each assay for individual species. Expand
Saliva oxytocin measures do not reflect peripheral plasma concentrations after intranasal oxytocin administration in men
TLDR
Saliva oxytocin appears to be a weak surrogate for peripheral blood measures after intranasal or intravenous Oxytocin administration, at least in men, according to data indicates. Expand
Intranasal oxytocin attenuates the cortisol response to physical stress: A dose–response study
TLDR
This is the first study to demonstrate that the effect of intranasal oxytocin on salivary cortisol is dose-dependent, and that intran asal Oxytocin attenuates cortisol levels in response to physical stress. Expand
Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice
TLDR
The data provide the first evidence that nasally applied OXT indeed reaches behaviorally relevant brain areas, and this uptake is paralleled by changes in plasma OXT. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 16 REFERENCES
The acute effects of intranasal oxytocin administration on endocrine and sexual function in males
TLDR
In conclusion, intranasally administered OT leads to a marked increase in OT plasma levels together with increased secretion of catecholamines when subjects are engaged in sexual activity in a laboratory setting. Expand
Detection of salivary oxytocin levels in lactating women.
TLDR
It is suggested that oxytocin release into saliva increases in anticipation of feedings, which supports the potential usefulness of salivary measures of Oxytocin as a noninvasive index of changes in this peptide. Expand
Oxytocin: behavioral associations and potential as a salivary biomarker.
TLDR
Using a sensitive enzyme immunoassay (EIA) and concentrated samples, the results indicate that measurements of biologically relevant changes in salivary OT are possible and support saliva as a noninvasive source to monitor central neuroendocrine function. Expand
Plasma oxytocin concentrations in man after different routes of administration of synthetic oxytocin.
  • R. Landgraf
  • Medicine
  • Experimental and clinical endocrinology
  • 1985
TLDR
Plasma oxytocin was determined by RIA in three male subjects under basal conditions and following administration of synthetic oxytocIn each case, plasma vasopressin remained unchanged. Expand
A review of safety, side-effects and subjective reactions to intranasal oxytocin in human research
BACKGROUND Human research investigating the impact of intranasal oxytocin on psychological processes has accelerated over the last two decades. No review of side effects, subjective reactions andExpand
Oxytocin is not a valid biomarker when measured in saliva by immunoassay
TLDR
It is stated with a high degree of certainty that measurement of OT in saliva does not yield meaningful indices of individual differences or intra-individual change and is not a valid salivary biomarker when measured by currently available immunological methods. Expand
Oxytocin and the Development of Parenting in Humans
TLDR
Results are the first to describe plasma OT levels in new fathers and mothers across the transition to parenthood in relation to maternal and paternal typical parenting behaviors and may provide a normative basis for the study of parenting under conditions of high risk. Expand
The peptide that binds: a systematic review of oxytocin and its prosocial effects in humans.
TLDR
Key conclusions are (1) human research with intranasal oxytocin has uniquely enhanced the authors' understanding of the microstructure and function of the human social brain, and (2) the Oxytocin system is a promising target for therapeutic interventions in a variety of conditions, especially those characterized by anxiety and aberrations in social function. Expand
Natural variations in maternal and paternal care are associated with systematic changes in oxytocin following parent–infant contact
TLDR
The findings underscore the need to provide opportunities for paternal care to trigger the biological basis of fatherhood and suggest that interventions that permit social engagement may be recommended in conditions of diminished maternal-infant contact, such as prematurity or postpartum depression. Expand
Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior
TLDR
The role of oxytocin in the regulation of prosocial interactions is reviewed, the neuroanatomy of the central oxytocIn system is discussed, and the nature of Oxytocin release within the brain is discussed. Expand
...
1
2
...