Intranasal oxytocin administration is reflected in human saliva

@article{Weisman2012IntranasalOA,
  title={Intranasal oxytocin administration is reflected in human saliva},
  author={Omri Weisman and Orna Zagoory-Sharon and Ruth Feldman},
  journal={Psychoneuroendocrinology},
  year={2012},
  volume={37},
  pages={1582-1586}
}

Figures and Tables from this paper

Salivary Oxytocin Concentrations in Males following Intranasal Administration of Oxytocin: A Double-Blind, Cross-Over Study

The results are consistent with previous research in suggesting that salivary OT is a valid matrix for OT measurement and suggest that the post-administration ‘wait-time’ prior to starting experimental tasks could be reduced to 30 minutes, from the 45 minutes typically used, thereby enabling testing during peak OT concentrations.

Increased Serum and Urinary Oxytocin Concentrations after Nasal Administration in Beagle Dogs

The results confirm that intranasally administered oxytocin passes into the blood stream and the peak values are also similar in both the serum and the urinary Oxytocin concentration measurements, although there are large individual differences.

Intranasal administration of oxytocin: Behavioral and clinical effects, a review

Temporal dynamics of intranasal oxytocin in human brain electrophysiology

It is posit IN-OT may tune the brain for reception of external stimuli, particularly of social nature—tentatively supporting current neurocognitive hypotheses of OT, and contrast the overall results against a comprehensive literature review of In-OT time-course effects in the brain.

Oxytocin administration affects the production of multiple hormones

Elevated Salivary Levels of Oxytocin Persist More than 7 h after Intranasal Administration

The increase of oxytocin levels for at least 7 h shows how effective intranasal administration of oxycoetocin is, and may raise ethical questions about potentially persisting behavioral effects after participants have left the lab setting.

Utility of Downstream Biomarkers to Assess and Optimize Intranasal Delivery of Oxytocin

It is found significantly higher uOT and pOT following intranasal delivery of active compound versus placebo, but analyses yielded larger effect sizes and more clearly differentiated pre–post-OT levels for uOT than pOT.
...

References

SHOWING 1-10 OF 16 REFERENCES

The acute effects of intranasal oxytocin administration on endocrine and sexual function in males

Detection of salivary oxytocin levels in lactating women.

It is suggested that oxytocin release into saliva increases in anticipation of feedings, which supports the potential usefulness of salivary measures of Oxytocin as a noninvasive index of changes in this peptide.

Plasma oxytocin concentrations in man after different routes of administration of synthetic oxytocin.

  • R. Landgraf
  • Medicine, Biology
    Experimental and clinical endocrinology
  • 1985
Plasma oxytocin was determined by RIA in three male subjects under basal conditions and following administration of synthetic oxytocIn each case, plasma vasopressin remained unchanged.

Oxytocin is not a valid biomarker when measured in saliva by immunoassay

Oxytocin and the Development of Parenting in Humans

The peptide that binds: a systematic review of oxytocin and its prosocial effects in humans.

Key conclusions are (1) human research with intranasal oxytocin has uniquely enhanced the authors' understanding of the microstructure and function of the human social brain, and (2) the Oxytocin system is a promising target for therapeutic interventions in a variety of conditions, especially those characterized by anxiety and aberrations in social function.

Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior

Neuropeptides and social behaviour: effects of oxytocin and vasopressin in humans.