Intranasal oxycodone self-administration in non-dependent opioid abusers.

@article{Middleton2012IntranasalOS,
  title={Intranasal oxycodone self-administration in non-dependent opioid abusers.},
  author={Lisa Sue Middleton and Michelle R. Lofwall and Paul A. Nuzzo and Anthony J. Siegel and Sharon L. Walsh},
  journal={Experimental and clinical psychopharmacology},
  year={2012},
  volume={20 4},
  pages={310-7}
}
Oxycodone, an opioid with known abuse liability, is misused by the intranasal route. Our objective was to develop a model of intranasal oxycodone self-administration useful for assessing the relative reinforcing effects of opioids and potential pharmacotherapies for opioid use disorders. Healthy, sporadic intranasal opioid abusers (n = 8; 7 M, 1 F) completed this inpatient 2.5-week, randomized, double-blind, placebo-controlled, crossover study. Each intranasal oxycodone dose (0, 14 & 28 mg) was… CONTINUE READING

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