Intranasal neuropeptide Y reverses anxiety and depressive-like behavior impaired by single prolonged stress PTSD model.

@article{Serova2014IntranasalNY,
  title={Intranasal neuropeptide Y reverses anxiety and depressive-like behavior impaired by single prolonged stress PTSD model.},
  author={Lidia I. Serova and Marcela Laukov{\'a} and Lishay G Alaluf and Leo Pucillo and Esther L. Sabban},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={2014},
  volume={24 1},
  pages={142-7}
}
PTSD is a debilitating neuropsychiatric disorder and many patients do not respond sufficiently to current treatments. Neuropeptide Y (NPY) is suggested to provide resilience to the development of PTSD and co-morbid depression. Injections of NPY to the rodent brain are anxiolytic. Recently we showed that intranasal delivery of NPY to rats before or immediately after exposure to single prolonged stress (SPS) animal model of PTSD prevented development of many biochemical and behavioral symptoms of… CONTINUE READING
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