Intranasal nerve growth factor enhances striatal neurogenesis in adult rats with focal cerebral ischemia

@article{Zhu2011IntranasalNG,
  title={Intranasal nerve growth factor enhances striatal neurogenesis in adult rats with focal cerebral ischemia},
  author={Wusheng Zhu and S. Cheng and Gelin Xu and Min-min Ma and Z. Zhou and Dezhi Liu and Xinfeng Liu},
  journal={Drug Delivery},
  year={2011},
  volume={18},
  pages={338 - 343}
}
Nerve growth factor (NGF) has been proved with the potential of promoting neurogenesis in adult mammalians. This study was aimed to investigate the effect of intranasal (IN) NGF on striatal neurogenesis and functional recovery in adult rats with focal cerebral ischemia. Rats were subjected to middle cerebral artery occlusion (MCAO) for 2 h, and then reperfused. NGF or vehicle was intranasally administered 24 h after cerebral reperfusion, and the treatments continued for 6 consecutive days there… Expand
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References

SHOWING 1-10 OF 35 REFERENCES
Intranasal delivery of transforming growth factor-beta1 in mice after stroke reduces infarct volume and increases neurogenesis in the subventricular zone
TLDR
Intranasal treatment of TGF-β1 shows significant improvement in neurological function and reduction of infarct volume compared with control animals, and may have therapeutic potential for cerebrovascular disorders. Expand
Expression of nerve growth factor and trkA after transient focal cerebral ischemia in rats.
TLDR
The data suggest that the NGF/receptor system may play a role in the astrocyte/neuron interaction under certain pathological conditions, such as focal cerebral ischemia in rats, and demonstrate a temporal profile of NGF and trkA in the ischemic cortex and NGF expression by reactiveAstrocytes. Expand
Nerve growth factor promotes survival of new neurons in the adult hippocampus
TLDR
Findings suggest that NGF, likely mediated through increased cholinergic tone, promotes neurogenesis in the adult hippocampus, which may relate to the nootropic action of NGF. Expand
Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat
  • K. Jin, M. Minami, +4 authors D. Greenberg
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
TLDR
A role for ischemia-induced neurogenesis in what may be adaptive processes that contribute to recovery after stroke is supported. Expand
Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia
TLDR
It is suggested that focal cerebral ischemia induces transient and regional specific increases in cell proliferation in the ipsilateral hemisphere and that proliferating progenitor cells may exist in the adult cortex. Expand
Intranasal Administration of Nerve Growth Factor Produces Antidepressant-Like Effects in Animals
Many works showed that nerve growth factor (NGF) injected into the brain of animal model emerges potential antidepressant effects. However, this route of administration significantly restricts theExpand
Neural stem cells and cholinergic neurons: Regulation by immunolesion and treatment with mitogens, retinoic acid, and nerve growth factor
TLDR
The results suggest that pharmacological control of endogenous neural stem cells can provide an additional opportunity for brain repair, and offer useful information for improving integration of transplanted cells into the mature brain. Expand
Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice.
TLDR
The Alzheimer-like neurodegeneration in AD11 mice is linked to progressive behavioral deficits in visual recognition memory and spatial memory starting from 4 months of age, and this route of administration provides a promising way to deliver NGF to the brain in a therapeutic perspective. Expand
Non-invasive intranasal insulin-like growth factor-I reduces infarct volume and improves neurologic function in rats following middle cerebral artery occlusion
TLDR
This study indicates IN delivery of IGF-1 holds significant promise as a non-invasive and efficacious method of bypassing the BBB for the treatment of stroke. Expand
Therapeutic Benefit of Intravenous Administration of Bone Marrow Stromal Cells After Cerebral Ischemia in Rats
  • Jieli Chen, Yi Li, +4 authors M. Chopp
  • Medicine
  • Stroke
  • 2001
TLDR
MSCs delivered to ischemic brain tissue through an intravenous route provide therapeutic benefit after stroke and may provide a powerful autoplastic therapy for stroke. Expand
...
1
2
3
4
...