Intranasal midazolam in piglets: pharmacodynamics (0.2 vs 0.4 mg/kg) and pharmacokinetics (0.4 mg/kg) with bioavailability determination

@article{Lacoste2000IntranasalMI,
  title={Intranasal midazolam in piglets: pharmacodynamics (0.2 vs 0.4 mg/kg) and pharmacokinetics (0.4 mg/kg) with bioavailability determination},
  author={Lucien J. B. Lacoste and Serge Bouquet and Pierre Ingrand and J. C. Caritez and Michel Carretier and Bertrand Debaene},
  journal={Laboratory Animals},
  year={2000},
  volume={34},
  pages={29 - 35}
}
Intranasal midazolam was studied in two series of piglets: series 1, n = 20 (18 ± 3 kg), a randomized double blind pharmacodynamic study to compare doses of 0.2 mg/kg and 0.4 mg/kg; series 2, n = 9 (42 ± 8 kg), a pharmacokinetic study with a 0.4 mg/kg dose administered either intravenously (i.v.) or intranasally (i.n.) in a cross-over protocol with a one-week wash-out period between each. In series 1, midazolam caused significant anxiolysis and sedation within 3 to 4 min, without a significant… CONTINUE READING

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The utility of the minipig as an animal model in regulatory toxicology.

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