Intranasal interleukin-12 treatment promotes antimicrobial clearance and survival in pulmonary Francisella tularensis subsp. novicida infection.

@article{Pammit2004IntranasalIT,
  title={Intranasal interleukin-12 treatment promotes antimicrobial clearance and survival in pulmonary Francisella tularensis subsp. novicida infection.},
  author={Michael A Pammit and Varija N Budhavarapu and Erin K Raulie and Karl Klose and Judy M. Teale and Bernard. P. Arulanandam},
  journal={Antimicrobial agents and chemotherapy},
  year={2004},
  volume={48 12},
  pages={4513-9}
}
Francisella tularensis is a highly virulent facultative intracellular bacterium and is considered a potential biological warfare agent. Inhalation tularemia can lead to the development of bronchopneumonia, which is frequently fatal without medical intervention. Treatment strategies that directly target the respiratory mucosa may extend the efficacy of therapy, particularly for the medical management of acute aerosol exposure. To this end, we describe an intranasal (i.n.) strategy for the… CONTINUE READING