Intranasal interleukin-12 treatment for protection against respiratory infection with the Francisella tularensis live vaccine strain.


Francisella tularensis is a gram-negative intracellular bacterium that can induce lethal respiratory infection in humans and rodents. However, little is known about the role of innate or adaptive immunity in protection from respiratory tularemia. In the present study, the role of interleukin-12 (IL-12) in inducing protective immunity in the lungs against… (More)


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