Intranasal insulin treatment of an experimental model of moderate traumatic brain injury.

@article{Brabazon2017IntranasalIT,
  title={Intranasal insulin treatment of an experimental model of moderate traumatic brain injury.},
  author={Fiona Brabazon and Colin M. Wilson and Shalini Jaiswal and John Reed and William H. Frey and Kimberly R Byrnes},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2017},
  volume={37 9},
  pages={
          3203-3218
        }
}
Traumatic brain injury (TBI) results in learning and memory dysfunction. Cognitive deficits result from cellular and metabolic dysfunction after injury, including decreased cerebral glucose uptake and inflammation. This study assessed the ability of intranasal insulin to increase cerebral glucose uptake after injury, reduce lesion volume, improve memory and learning function and reduce inflammation. Adult male rats received a controlled cortical impact (CCI) injury followed by intranasal… CONTINUE READING
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