Intranasal insulin improves memory in humans

@article{Benedict2004IntranasalII,
  title={Intranasal insulin improves memory in humans},
  author={C. Benedict and M. Hallschmid and A. Hatke and B. Schultes and H. Fehm and J. Born and W. Kern},
  journal={Psychoneuroendocrinology},
  year={2004},
  volume={29},
  pages={1326-1334}
}
Previous studies have suggested an acutely improving effect of insulin on memory function. To study changes in memory associated with a prolonged increase in brain insulin activity in humans, here we used the intranasal route of insulin administration known to provide direct access of the substance to the cerebrospinal fluid compartment. Based on previous results indicating a prevalence of insulin receptors in limbic and hippocampal regions as well as improvements in memory with systemic… Expand
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References

SHOWING 1-10 OF 44 REFERENCES
Improving Influence of Insulin on Cognitive Functions in Humans
TLDR
Results indicate an improving effect of insulin on cognitive function, and may provide a frame for further investigations of neurobehavioral effects of insulin in patients with lowered or enhanced brain insulin, i.e., patients with Alzheimer’s disease or diabetes mellitus. Expand
Central nervous system effects of intranasally administered insulin during euglycemia in men.
TLDR
The results suggest that after intranasal administration, insulin directly enters the brain and exerts distinct influences on central nervous functions in humans. Expand
Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucose.
TLDR
It is confirmed that elevated insulin without hyperglycemia enhances memory in adults with AD, and indicates that insulin is essential for hyperglycemic memory facilitation. Expand
Intracerebroventricular insulin enhances memory in a passive-avoidance task
TLDR
Whether intracerebroventricular administration of insulin improves memory formation in rats is determined and rats receiving insulin after being shocked had an increased latency to enter the dark compartment, compared to those rats that had received saline or heat-deactivated insulin after shock. Expand
Carbohydrate-induced memory impairment in adults with type 2 diabetes.
TLDR
In adults with type 2 diabetes, poorer glycemic control is associated with lower performance on tests of declarative memory and high glycemic index carbohydrate foods further contributes to the underlying memory impairment. Expand
Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats.
TLDR
Adult rats with icv-injected STZ developed long-term and progressive deficits in learning, memory, and cognitive behavior, indicated by decreases in working and reference memory in the holeboard task and the passive avoidance paradigm, along with a permanent and ongoing cerebral energy deficit. Expand
The cellular and physiological actions of insulin in the central nervous system
TLDR
Evidence exists in support of both peripheral and central origins of this hormone in the brain, and theories concerning the origin of insulin in the CNS are discussed. Expand
Brain corticosteroid receptor balance in health and disease.
TLDR
The balance in actions mediated by the two corticosteroid receptor types in these neurons appears critical for neuronal excitability, stress responsiveness, and behavioral adaptation and Dysregulation of this MR/GR balance brings neurons in a vulnerable state with consequences for regulation of the stress response and enhanced vulnerability to disease in genetically predisposed individuals. Expand
Attentionally modulated effects of cortisol and mood on memory for emotional faces in healthy young males
TLDR
Both the levels of cortisol and depressive mood were inversely related to the memory performance for the happy facial expressions, while a similar relationship between cortisol and memory performance on angry faces neared significance. Expand
Adaptation of cognitive function to hypoglycemia in healthy men.
TLDR
Data provide evidence that a single episode of mild antecedent hypoglycemia attenuates several aspects of cognitive dysfunction during subsequent hypoglyCEmia 18-24 h later. Expand
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