Intranasal insulin improves memory in humans

@article{Benedict2004IntranasalII,
  title={Intranasal insulin improves memory in humans},
  author={Christian Benedict and M. Hallschmid and A. Hatke and B. Schultes and W. Kern},
  journal={Psychoneuroendocrinology},
  year={2004},
  volume={29},
  pages={1326-1334}
}
  • Christian Benedict, M. Hallschmid, +2 authors W. Kern
  • Published 2004
  • Psychology, Medicine
  • Psychoneuroendocrinology
  • Previous studies have suggested an acutely improving effect of insulin on memory function. To study changes in memory associated with a prolonged increase in brain insulin activity in humans, here we used the intranasal route of insulin administration known to provide direct access of the substance to the cerebrospinal fluid compartment. Based on previous results indicating a prevalence of insulin receptors in limbic and hippocampal regions as well as improvements in memory with systemic… CONTINUE READING
    539 Citations

    Figures, Tables, and Topics from this paper.

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    The SNIFF Device study will involve using one of three devices to administer insulin through each participant's nose or intra-nasally, accompanied by a lumbar puncture. This goal of this… Expand
    ConditionsCognitive Impairment, Mild Cognitive Impairment
    InterventionDrug
    INTERVENTIONAL CLINICAL TRIAL
    This study aims to see whether intranasal insulin is an effective treatment for problems with memory, concentration, slowed thinking, or any other cognitive function in people living… Expand
    ConditionsHIV Associated Neurocognitive Disorder (HAND)
    InterventionBiological
    INTERVENTIONAL CLINICAL TRIAL
    The SNIFF Device study will involve using a device to administer insulin through each participant's nose or intra-nasally. Insulin is a hormone that is produced in the body. It… Expand
    ConditionsCognitive Impairment, Mild Cognitive Impairment
    InterventionDevice, Drug, Other
    Intranasal Insulin to Improve Memory Function in Humans
    • 136
    Intranasal Insulin Improves Memory in Humans: Superiority of Insulin Aspart
    • 226
    • PDF
    Effects of intranasal insulin on cognition in memory-impaired older adults: Modulation by APOE genotype
    • 498
    • Highly Influenced
    • PDF
    Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults.
    • 406
    • Highly Influenced
    Intranasal insulin as a therapeutic option in the treatment of cognitive impairments
    • 116
    • PDF
    Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin.
    • 216
    • PDF
    Intranasal Insulin Improves Age-Related Cognitive Deficits and Reverses Electrophysiological Correlates of Brain Aging.
    • 50
    • PDF
    Awake, long-term intranasal insulin treatment does not affect object memory, odor discrimination, or reversal learning in mice
    • 17
    • PDF
    Metabolic and Cognitive Outcomes of Subchronic Once-Daily Intranasal Insulin Administration in Healthy Men
    • 3
    • PDF

    References

    SHOWING 1-10 OF 44 REFERENCES
    Improving Influence of Insulin on Cognitive Functions in Humans
    • 273
    Central nervous system effects of intranasally administered insulin during euglycemia in men.
    • 170
    Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucose.
    • 298
    • PDF
    Intracerebroventricular insulin enhances memory in a passive-avoidance task
    • 313
    Carbohydrate-induced memory impairment in adults with type 2 diabetes.
    • 90
    • PDF
    Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats.
    • 456
    • Highly Influential
    The cellular and physiological actions of insulin in the central nervous system
    • 197
    Brain corticosteroid receptor balance in health and disease.
    • 2,391
    • PDF
    Attentionally modulated effects of cortisol and mood on memory for emotional faces in healthy young males
    • 64