Intranasal insulin improves cognition and modulates-amyloid in early AD

  title={Intranasal insulin improves cognition and modulates-amyloid in early AD},
  author={Mark A. Reger and Ginger S. Watson and Pattie S. Green and Charles W Wilkinson and Laura D. Baker and Brenna A. Cholerton and Mark Fishel and Stephen R. Plymate and John C. S. Breitner and W. DeGroodt and Priyesh Mehta and Suzanne Craft},
Background: Reduced brain insulin signaling and low CSF-to-plasma insulin ratios have been observed in patients with Alzheimer disease (AD). Furthermore, intracerebroventricular or IV insulin administration improve memory, alter evoked potentials, and modulate neurotransmitters, possibly by augmenting low brain levels. After intranasal administration, insulin-like peptides follow extracellular pathways to the brain within 15 minutes. Objective: We tested the hypothesis that daily intranasal… CONTINUE READING


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