Intranasal insulin affects adenyl cyclase system in rat tissues in neonatal diabetes

@article{Shpakov2011IntranasalIA,
  title={Intranasal insulin affects adenyl cyclase system in rat tissues in neonatal diabetes},
  author={Alexander Olegovich Shpakov and Oksana V. Chistyakova and Kira V. Derkach and Irina V. Moyseyuk and Vera M. Bondareva},
  journal={Central European Journal of Biology},
  year={2011},
  volume={7},
  pages={33-47}
}
The changes in hormone-regulated adenylyl cyclase (AC) signaling system implicated in control of the nervous, cardiovascular and reproductive systems may contribute to complications of diabetes mellitus (DM). We investigated the functional state of AC system in the brain, myocardium, ovary and uterus of rats with neonatal DM and examined the influence of intranasally administered insulin on the sensitivity of this system to biogenic amines and polypeptide hormones. The regulatory effects of… CONTINUE READING

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