Intranasal immunization with vaccine vector Streptococcus gordonii elicits primed CD4+ and CD8+ T cells in the genital and intestinal tracts.

@article{Ciabattini2010IntranasalIW,
  title={Intranasal immunization with vaccine vector Streptococcus gordonii elicits primed CD4+ and CD8+ T cells in the genital and intestinal tracts.},
  author={Annalisa Ciabattini and Elena Pettini and Slavica Arsenijevic and Gianni Arrigo Pozzi and Donata Medaglini},
  journal={Vaccine},
  year={2010},
  volume={28 5},
  pages={
          1226-33
        }
}
Generation of primed T cells is crucial for the development of optimal vaccination strategies. Using a TCR-transgenic CD4(+) and CD8(+) T cell adoptive transfer model, we demonstrate that a single nasal immunization with recombinant Streptococcus gordonii induces antigen-specific primed T cells in lymph nodes draining the genital and intestinal tracts with about 80% of CD4(+) and 50% of CD8(+) proliferating cells. T cell clonal expansion was also observed in cervical lymph nodes, draining the… CONTINUE READING
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