Intranasal immunization with mumps virus DNA vaccine delivered by influenza virosomes elicits mucosal and systemic immunity.

@article{Cusi2000IntranasalIW,
  title={Intranasal immunization with mumps virus DNA vaccine delivered by influenza virosomes elicits mucosal and systemic immunity.},
  author={Maria Grazia Cusi and Rinaldo Zurbriggen and Marcello Valassina and Silvia Bianchi and Peter Durrer and Pier Egisto Valensin and Manuela Donati and Reinhard Glück},
  journal={Virology},
  year={2000},
  volume={277 1},
  pages={
          111-8
        }
}
To improve the efficiency of liposome-mediated DNA transfer as a tool for gene therapy or vaccinology, we have further developed a new delivery system based on the modified immunopotentiating reconstituted influenza virus (IRIV). In this study, we engineered a plasmid DNA vector expressing the mumps virus hemagglutinin or the fusion protein. The administration of this DNA vaccine delivered by influenza virosomes, in combination with the mucosal adjuvant Escheriagen via the intranasal route, was… 
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    Trends in immunology
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Fusion-active influenza virosomes represent an excellent vaccine delivery system for induction of cellular immunity against encapsulated HPV16 E7 and are a promising immunotherapeutic vaccine for treatment of (presursor lesions of) cervical cancer.
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DNA Vaccines for the Induction of Immune Responses in Mucosal Tissues
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