Intranasal immunization with live recombinant Lactococcus lactis combined with heat-labile toxin B subunit protects chickens from highly pathogenic avian influenza H5N1 virus.

@article{Lei2015IntranasalIW,
  title={Intranasal immunization with live recombinant Lactococcus lactis combined with heat-labile toxin B subunit protects chickens from highly pathogenic avian influenza H5N1 virus.},
  author={Han Lei and Xiaojue Peng and Handing Shu and Daxian Zhao},
  journal={Journal of medical virology},
  year={2015},
  volume={87 1},
  pages={39-44}
}
Development of safe and effective vaccines to prevent highly pathogenic avian influenza H5N1 virus infection is a challenging goal. Lactococcus lactis (L. lactis) is an ideal delivery vector for vaccine development, and it has been shown previously that oral immunization of encapsulated secretory L. lactis-hemagglutinin (HA) could provide complete protection against homologous H5N1 virus challenge in the mice model. While intranasal immunization is an appealing approach, it is now reported that… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 17 references

from laboratory bench to human use : An overview

LG Bermúdez-Humarán, P Kharrat, JM Chatel, P Langella
2011
View 1 Excerpt

Similar Papers

Loading similar papers…