Intranasal immunization with gonococcal outer membrane preparations reduces the duration of vaginal colonization of mice by Neisseria gonorrhoeae.

@article{Plante2000IntranasalIW,
  title={Intranasal immunization with gonococcal outer membrane preparations reduces the duration of vaginal colonization of mice by Neisseria gonorrhoeae.},
  author={Matthew Plante and Ann E Jerse and Jos{\'e}e Hamel and France Couture and Cl{\'e}ment R. Rioux and Bernard R. Brodeur and Denis Nicol{\'a}s Martin},
  journal={The Journal of infectious diseases},
  year={2000},
  volume={182 3},
  pages={
          848-55
        }
}
Nasal immunization was studied to determine if it could elicit an immune response capable of preventing vaginal colonization by Neisseria gonorrhoeae or of reducing its duration in the estradiol-treated mouse model. Nasal administration of gonococcal outer membrane (OM) preparations induced the development of systemic and vaginal immune responses that were directed mainly against a limited number of gonococcal OM proteins. The impact of nasal immunization on vaginal colonization by N… CONTINUE READING
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