Intranasal immunization promotes th17 immune responses.

@article{Zygmunt2009IntranasalIP,
  title={Intranasal immunization promotes th17 immune responses.},
  author={Beata M. Zygmunt and Faiza Rharbaoui and Lothar Groebe and Carlos Alberto Guzm{\'a}n},
  journal={Journal of immunology},
  year={2009},
  volume={183 11},
  pages={6933-8}
}
Th17 cells are a lineage of CD4+ T cells characterized by IL-17 secretion, which plays a crucial role in immune responses against important respiratory pathogens, such as Mycobacterium tuberculosis. In this study, we demonstrated that intranasal (i.n.) immunization leads per se to Th17-biased immune responses, regardless of the adjuvant used. The activated CD4+ T cells also showed an up-regulated expression of the chemokine receptor CCR6, which is a marker for murine Th17 cells. These results… CONTINUE READING

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