Intranasal immunization of mutant toxic shock syndrome toxin 1 elicits systemic and mucosal immune response against Staphylococcus aureus infection.

@article{Narita2008IntranasalIO,
  title={Intranasal immunization of mutant toxic shock syndrome toxin 1 elicits systemic and mucosal immune response against Staphylococcus aureus infection.},
  author={Kouji Narita and Dong-Liang Hu and Takao Tsuji and Akio Nakane},
  journal={FEMS immunology and medical microbiology},
  year={2008},
  volume={52 3},
  pages={389-96}
}
We investigated whether an intranasal immunization with mutant toxic shock syndrome toxin 1 (TSST-1) could elicit a protective effect against nasal colonization as well as systemic infection of Staphyloccoccus aureus in a mouse model. Anti-TSST-1 antibody production in the mucosal exudates and in sera was efficiently induced. Bacterial numbers were reduced in spleen, liver and also nasal cavities in the early stage of nasal colonization, and the survival rate was significantly improved in the… CONTINUE READING
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