Intranasal immunization of mice with a formalin-inactivated bovine respiratory syncytial virus vaccine co-formulated with CpG oligodeoxynucleotides and polyphosphazenes results in enhanced protection.

@article{Mapletoft2008IntranasalIO,
  title={Intranasal immunization of mice with a formalin-inactivated bovine respiratory syncytial virus vaccine co-formulated with CpG oligodeoxynucleotides and polyphosphazenes results in enhanced protection.},
  author={John W Mapletoft and Mustapha Oumouna and Jennifer Kovacs-Nolan and Laura J. P. Latimer and George K. Mutwiri and Lorne A. Babiuk and Sylvia van Drunen Littel-van den Hurk},
  journal={The Journal of general virology},
  year={2008},
  volume={89 Pt 1},
  pages={250-60}
}
  • John W Mapletoft, Mustapha Oumouna, +4 authors Sylvia van Drunen Littel-van den Hurk
  • Published 2008 in The Journal of general virology
As respiratory syncytial virus (RSV) targets the mucosal surfaces of the respiratory tract, induction of both systemic and mucosal immunity will be critical for optimal protection. In this study, the ability of an intranasally delivered, formalin-inactivated bovine RSV (FI-BRSV) vaccine co-formulated with CpG oligodeoxynucleotides (ODN) and polyphosphazenes (PP) to induce systemic and mucosal immunity, as well as protection from BRSV challenge, was evaluated. Intranasal immunization of mice… CONTINUE READING

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