Intranasal exposure to protein antigen induces immunological tolerance mediated by functionally disabled CD4+ T cells.

@article{Tsitoura1999IntranasalET,
  title={Intranasal exposure to protein antigen induces immunological tolerance mediated by functionally disabled CD4+ T cells.},
  author={Daphne C. Tsitoura and Rosemarie H. Dekruyff and Jonathan Robert Lamb and Dale T. Umetsu},
  journal={Journal of immunology},
  year={1999},
  volume={163 5},
  pages={2592-600}
}
In this study we examined the immunological parameters underlying the natural immunity to inhaled nonpathogenic proteins. We addressed this question by examining the effect of intranasal exposure to OVA in both wild-type mice and mice reconstituted with OVA-TCR transgenic CD4+ T cells. Intranasal administration of OVA induced an initial phase of activation during which CD4+ T cells were capable of proliferating and producing cytokines. Although many of the OVA-specific CD4+ T cells were… CONTINUE READING
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