Intranasal exposure to Stachybotrys chartarum enhances airway inflammation in allergic mice.

@article{Leino2006IntranasalET,
  title={Intranasal exposure to Stachybotrys chartarum enhances airway inflammation in allergic mice.},
  author={Marina S. Leino and Harri Alenius and Nanna Fyhrquist-Vanni and Henrik J. Wolff and Kari E Reijula and E L Hintikka and Mirja S. Salkinoja-Salonen and Tari Haahtela and Mika Juhani M{\"a}kel{\"a}},
  journal={American journal of respiratory and critical care medicine},
  year={2006},
  volume={173 5},
  pages={512-8}
}
RATIONALE Exposure to building dampness, often associated with growth of microbes such as Stachybotrys chartarum, has been linked to respiratory symptoms. We have shown previously in a murine model that exposure to S. chartarum can induce lung inflammation characterized by infiltration of neutrophils and lymphocytes; this process is regulated by proinflammatory cytokines and leucocyte-attracting chemokines. OBJECTIVES Because an atopic predisposition may influence the response to microbes, we… CONTINUE READING

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