Intranasal delivery of nerve growth factor attenuates aquaporins-4-induced edema following traumatic brain injury in rats.

@article{Lv2013IntranasalDO,
  title={Intranasal delivery of nerve growth factor attenuates aquaporins-4-induced edema following traumatic brain injury in rats.},
  author={Qiushi Lv and Xinying Fan and Gelin Xu and Qian Liu and Lili Tian and Xiaoyi Cai and Wenshan Sun and Xiaomeng Wang and Qiankun Cai and Yuanfei Bao and Lulu Zhou and Yao Zhang and Liang Ge and Ruibing Guo and Xinfeng Liu},
  journal={Brain research},
  year={2013},
  volume={1493},
  pages={80-9}
}
Traumatic brain injury (TBI) remains the leading cause of injury-related death and disability. Brain edema, one of the most major complications of TBI, contributes to elevated intracranial pressure, and poor prognosis following TBI. Nerve growth factor (NGF) appears to be a viable strategy to treat brain edema and TBI. Unfortunately, due to its poor blood-brain barrier (BBB) permeability, the clinical application of NGF has been greatly limited. We previously demonstrated that intranasal NGF… CONTINUE READING

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