Intranasal delivery of erythropoietin plus insulin-like growth factor-I for acute neuroprotection in stroke. Laboratory investigation.

Abstract

OBJECT Individually, the cytokines erythropoietin (EPO) and insulin-like growth factor-I (IGF-I) have both been shown to reduce neuronal damage significantly in rodent models of cerebral ischemia. The authors have previously shown that EPO and IGF-I, when administered together, provide acute and prolonged neuroprotection in cerebrocortical cultures against… (More)
DOI: 10.3171/2009.2.JNS081199

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@article{Fletcher2009IntranasalDO, title={Intranasal delivery of erythropoietin plus insulin-like growth factor-I for acute neuroprotection in stroke. Laboratory investigation.}, author={Lauren Fletcher and Sanjivan Kohli and Shane M Sprague and Robert A. Scranton and Stuart A. Lipton and Augusto Parra and David F. Jimenez and Murat H Digicaylioglu}, journal={Journal of neurosurgery}, year={2009}, volume={111 1}, pages={164-70} }