Intranasal delivery of HMGB1 siRNA confers target gene knockdown and robust neuroprotection in the postischemic brain.

@article{Kim2012IntranasalDO,
  title={Intranasal delivery of HMGB1 siRNA confers target gene knockdown and robust neuroprotection in the postischemic brain.},
  author={Il-Doo Kim and Joo-Hyun Shin and Seung-Woo Kim and Sunghyun Choi and Junseong Ahn and Pyung-Lim Han and Jong-sang Park and Ja-Kyeong Lee},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2012},
  volume={20 4},
  pages={
          829-39
        }
}
Noninvasive intranasal drug administration has been noted to allow direct delivery of drugs to the brain. In the present study, the therapeutic efficacy of intranasal small interfering RNA (siRNA) delivery was investigated in the postischemic rat brain. Fluorescein isothiocyanate (FITC)-labeled control siRNA was delivered intranasally in normal adult rats using e-PAM-R, a biodegradable PAMAM dendrimer, as gene carrier. Florescence-tagged siRNA was found in the cytoplasm and processes of neurons… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 32 CITATIONS

siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries

VIEW 7 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Dendrimers as Carriers for siRNA Delivery and Gene Silencing: A Review

  • TheScientificWorldJournal
  • 2013
VIEW 2 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Similar Papers

Loading similar papers…