Intranasal coadministration of the Cry1Ac protoxin with amoebal lysates increases protection against Naegleria fowleri meningoencephalitis.

@article{RojasHernandez2004IntranasalCO,
  title={Intranasal coadministration of the Cry1Ac protoxin with amoebal lysates increases protection against Naegleria fowleri meningoencephalitis.},
  author={S Rojas-Hernandez and Marco Aurelio Rodriguez-Monroy and Rub{\'e}n L{\'o}pez-Revilla and Aldo Arturo Res{\'e}ndiz-Albor and Leticia Moreno-Fierros},
  journal={Infection and immunity},
  year={2004},
  volume={72 8},
  pages={4368-75}
}
Cry1Ac protoxin has potent mucosal and systemic adjuvant effects on antibody responses to proteins or polysaccharides. In this work, we examined whether Cry1Ac increased protective immunity against fatal Naegleria fowleri infection in mice, which resembles human primary amoebic meningoencephalitis. Higher immunoglobulin G (IgG) than IgA anti-N. fowleri responses were elicited in the serum and tracheopulmonary fluids of mice immunized by the intranasal or intraperitoneal route with N. fowleri… CONTINUE READING