Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats

@article{Jiang2011IntranasalBN,
  title={Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats},
  author={Y. Jiang and N. Wei and T. Lu and J. Zhu and X. Liu},
  journal={Neuroscience},
  year={2011},
  volume={172},
  pages={398-405}
}
  • Y. Jiang, N. Wei, +2 authors X. Liu
  • Published 2011
  • Medicine
  • Neuroscience
  • Inflammation plays a vital role in the pathogenesis of ischemic stroke. Brain-derived neurotrophic factor (BDNF) may protect brain tissues from ischemic injury. In this study, we investigated whether intranasal BDNF exerted neuroprotection against ischemic insult by modulating the local inflammation in rats with ischemic stroke. Rats were subjected to temporary occlusion of the right middle cerebral artery (120 min) and intranasal BDNF or vehicle was adminstrated 2 h after reperfusion. Infarct… CONTINUE READING
    128 Citations
    Brain-derived neurotrophic factor reduces inflammation and hippocampal apoptosis in experimental Streptococcus pneumoniae meningitis
    • 42
    The neuroprotective roles of BDNF in hypoxic ischemic brain injury.
    • 148
    • PDF
    Local Injection of Lenti–BDNF at the Lesion Site Promotes M2 Macrophage Polarization and Inhibits Inflammatory Response After Spinal Cord Injury in Mice
    • 35
    Intranasal nerve growth factor attenuates tau phosphorylation in brain after traumatic brain injury in rats
    • 28
    Overexpression of brain-derived neurotrophic factor in the hippocampus protects against post-stroke depression
    • 21
    Secretomes of apoptotic mononuclear cells ameliorate neurological damage in rats with focal ischemia
    • 3
    • PDF
    Neuronal regeneration and protection by collagen-binding BDNF in the rat middle cerebral artery occlusion model.
    • 33

    References

    SHOWING 1-10 OF 36 REFERENCES
    Microglia provide neuroprotection after ischemia
    • 242
    Brain-Derived Neurotrophic Factor Induces Sustained Elevation of Intracellular Ca2+ in Rodent Microglia1
    • 52
    • PDF