Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats.


Inflammation plays a vital role in the pathogenesis of ischemic stroke. Brain-derived neurotrophic factor (BDNF) may protect brain tissues from ischemic injury. In this study, we investigated whether intranasal BDNF exerted neuroprotection against ischemic insult by modulating the local inflammation in rats with ischemic stroke. Rats were subjected to… (More)
DOI: 10.1016/j.neuroscience.2010.10.054


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