Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats

@article{Jiang2011IntranasalBN,
  title={Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats},
  author={Yongliang Jiang and Ning-ning Wei and T. Lu and Jiangbo Zhu and Xiaozhi Liu},
  journal={Neuroscience},
  year={2011},
  volume={172},
  pages={398-405}
}
Inflammation plays a vital role in the pathogenesis of ischemic stroke. Brain-derived neurotrophic factor (BDNF) may protect brain tissues from ischemic injury. In this study, we investigated whether intranasal BDNF exerted neuroprotection against ischemic insult by modulating the local inflammation in rats with ischemic stroke. Rats were subjected to temporary occlusion of the right middle cerebral artery (120 min) and intranasal BDNF or vehicle was adminstrated 2 h after reperfusion. Infarct… CONTINUE READING

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