Intranasal bioavailability of buprenorphine in rabbit correlated to sheep and man.

@article{Lindhardt2001IntranasalBO,
  title={Intranasal bioavailability of buprenorphine in rabbit correlated to sheep and man.},
  author={Karsten Lindhardt and Malene Bagger and K H Andreasen and Erik Bechgaard},
  journal={International journal of pharmaceutics},
  year={2001},
  volume={217 1-2},
  pages={121-6}
}
The purpose of the present study of buprenorphine is to add information about the correlation between various animal models and nasal bioavailabilities in man. PEG 300 was added to one formulation to study whether the addition of the co-solvent results in the same absorption pattern as seen for sheep. The bioavailability of intranasal buprenorphine 0.6 mg in PEG 300 and 5% dextrose was assessed in a cross-over study in six rabbits. The mean bioavailabilities, Tmax and Cmax were 46% (S.D. +/-13… CONTINUE READING