Intranasal and oral cocaine kinetics

@article{Wilkinson1980IntranasalAO,
  title={Intranasal and oral cocaine kinetics},
  author={Paul K. Wilkinson and Craig Van Dyke and Peter I. Jatlow and Paul Barash and Robert Byck},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1980},
  volume={27}
}
Plasma cocaine levels were determined in 7 subjects after intranasal and oral cocaine. Intranasal doses of 0.19, 0.38, 0.75, 1.5, and 2.0 mg/kg were given as a 10% aqueous solution; 0.38 mg/kg was given as crystalline cocaine HCl. Oral cocaine was administered in doses of 2.0 and 3.0 mg/kg. Intranasal cocaine kinetics were described by a 1‐compartment open model with 2 consecutive first‐order input steps and first‐order elimination. Oral cocaine disposition was described by a 1‐compartment open… 
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