Intranasal administration of neuropeptide Y in man: systemic absorption and functional effects

@article{Lacroix1996IntranasalAO,
  title={Intranasal administration of neuropeptide Y in man: systemic absorption and functional effects},
  author={J. Sylvain Lacroix and Alma Ricchetti and Denis R. Morel and B Mossimann and Bernard Waeber and Eric Grouzmann},
  journal={British Journal of Pharmacology},
  year={1996},
  volume={118}
}
1 Exogenous neuropeptide Y (NPY, 10 nmol, 50 nmol and 100 nmol) and its vehicle (NaCl 0.9%) were administered in a double blind, randomized and controlled manner by intranasal spray in 7 healthy volunteers. Variations of plasma NPY concentration over time were measured during 120 min. Forty min after the administration of 50 nmol and 100 nmol of exogenous NPY, plasma NPY increased from 5.5 ± 1.1 pM to 9.8 ± 2.3 pM (P < 0.05) and from 9.06 ± 5.1 pM to 20.8 ± 6.16 pM (P < 0.001), respectively… 

Functional effects of neuropeptide Y receptors on blood flow and nitric oxide levels in the human nose.

NPY is a potent vasoconstrictor in the human nose reducing mucosal blood flow, as well as the blood content, and intranasal nitric oxide (NO) concentration.

Post-exercise nasal vasoconstriction and hyporeactivity: possible involvement of neuropeptide Y.

Variations of plasma NPY concentrations over time correlated better with post-exercise nasal vasoconstriction and hyporeactivity to capsaicin than NA, suggesting that endogenous NPY could be involved in the prolonged post- exercise nasal vasocompletion and acts as a modulator of nasal airways reactivity.

Influence of TASP‐V, a novel neuropeptide Y (NPY) Y2 agonist, on nasal and bronchial responses evoked by histamine in anaesthetized pigs and in humans

It is concluded that intranasal or intrabronchial pretreatment with TASP‐V reduced nasal obstruction and bronchoconstriction evoked by histamine challenge in the pig and in healthy human volunteers, this agent attenuated NAR increase and MCSA reduction induced by intran asal application of histamine.

Neuropeptide Y (NPY).

Central functions of neuropeptide Y in mood and anxiety disorders

It is proposed that via this mode of administration, NPY might exert CNS therapeutic actions without untoward systemic effects, and the NPYergic system a promising target for the development of novel therapeutic interventions.

Neuropeptide Y: the universal soldier

NPY is involved in the regulatory loops that control food intake in the hypothalamus and appears also to be important for regulating the activity of neuroendocrine axes under poor metabolic conditions, which makes it an attractive target for the potential treatment of human diseases, such as obesity, metabolic disorders, hypertension and heart failure.

Neuropeptide Y (NPY) intranasal delivery alleviates Machado–Joseph disease

The findings support the translational potential of intranasal infusion of NPY as a pharmacological intervention in MJD and show a mitigation of motor and balance impairments through the analysis of mice behavioral tests.

Expression of NPY Y1 and CGRP1 Receptors in Human Nasal Mucosa: Implications in Allergic Rhinitis

The possibility of local release in connection with specific target receptors suggests a role for endogenous NPY and CGRP in the regulation of vascular tone, glandular secretion, and epithelial functions.

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