Intranasal administration of interferon beta bypasses the blood–brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis

@article{Ross2004IntranasalAO,
  title={Intranasal administration of interferon beta bypasses the blood–brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis},
  author={Ted M Ross and P. Mart{\'i}nez Mart{\'i}nez and Jennifer C. Renner and Robert G. Thorne and William H. Frey},
  journal={Journal of Neuroimmunology},
  year={2004},
  volume={151},
  pages={66-77}
}
Intranasal (i.n.) administration of IFN beta-1b was examined as a route for targeted delivery to the rat central nervous system (CNS). Intranasal administration resulted in significant delivery throughout the CNS and cervical lymph nodes with low delivery to peripheral organs. At similar blood levels, intravenous (i.v.) administration of IFN beta-1b yielded 88-98% lower CNS levels and 100-1650% greater peripheral organ levels compared to intranasal. Autoradiography confirmed much greater… CONTINUE READING

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