Intranasal administration of human IL-6 increases the severity of chemically induced seizures in rats.

@article{Kalueff2004IntranasalAO,
  title={Intranasal administration of human IL-6 increases the severity of chemically induced seizures in rats.},
  author={Allan Kalueff and Kai A Lehtimaki and Aarne Ylinen and Jari Honkaniemi and Jukka Peltola},
  journal={Neuroscience letters},
  year={2004},
  volume={365 2},
  pages={106-10}
}
Here we study the role of a pleiotropic pro-inflammatory cytokine, interleukin-6 (IL-6), in epilepsy. To examine this problem, we used human recombinant IL-6 applied intranasally (400 ng/40 microl) to rats 1h before seizures induced by systemic injection of pentylenenetrazole (PTZ, 75 mg/kg). Overall, compared to the saline-treated control animals (n = 11 in each group), IL-6-treated rats demonstrated elevated levels of IL-6 in the frontal lobe (measured by ELISA) and increased severity of PTZ… CONTINUE READING

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