Intranasal administration of aTf protects and repairs the neonatal white matter after a cerebral hypoxic–ischemic event

@article{GuardiaClausi2012IntranasalAO,
  title={Intranasal administration of aTf protects and repairs the neonatal white matter after a cerebral hypoxic–ischemic event},
  author={Mariano Guardia Clausi and Pablo M. Paez and Anthony T. Campagnoni and Laura Andrea Pasquini and Juana Mar{\'i}a Pasquini},
  journal={Glia},
  year={2012},
  volume={60}
}
Our previous studies showed that the intracerebral injection of apotransferrin (aTf) attenuates white matter damage and accelerates the remyelination process in a neonatal rat model of cerebral hypoxia‐ischemia (HI) injury. However, the intracerebral injection of aTf might not be practical for clinical treatments. Therefore, the development of less invasive techniques capable of delivering aTf to the central nervous system would clearly aid in its effective clinical use. In this work, we have… 
Inhalation of growth factors and apo-transferrin to protect and repair the hypoxic-ischemic brain.
TLDR
Recent publications demonstrate that the intranasal administration (INA) of apo-transferrin (aTf) and different growth factors provides neuroprotection to the mouse and rat brain after a hypoxic-ischemic event.
Intranasal Delivery of Exendin-4 Confers Neuroprotective Effect Against Cerebral Ischemia in Mice
TLDR
Evidence is provided that exendin-4 intranasal administration exerted a neuroprotective effect mediated by an anti-apoptotic mechanism in MCAO mice and protected neurons against ischemic injury through the GLP-1R pathway in the brain.
Hypoxic-Ischemic Neonatal Encephalopathy: Animal Experiments for Neuroprotective Therapies
TLDR
The results of the recent studies on neuroprotective therapies in animal experiments are shared, as well as some literature reviews, to establish an individualized strategy for neuroprotection against perinatal hypoxic-ischemic insult.
Intranasal surfactant protein D as neuroprotective rescue in a neonatal rat model of periventricular leukomalacia
  • A. Kumral, B. Iscan, +6 authors H. Ozkan
  • Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2017
TLDR
It is demonstrated that surfactant protein D with its ability to bind toll-like receptors may have a possible ameliorating effect in PVL by demonstrating a neuroprotective effect of SPD in a rat model of PVL.
Pharmacological approaches to intervention in hypomyelinating and demyelinating white matter pathology
TLDR
By surveying the current evidence in non-immune targets of both the immature and mature WM, it is aimed to better understand pharmacological approaches modulating endogenous oligodendroglia that show potential for success in the contexts of developmental and adult WM pathology.
eview nhalation of growth factors and apo-transferrin to protect and repair he hypoxic-ischemic brain
Hypoxic-ischemic brain damage is a major contributor to chronic neurological dysfunction and acute mortality in infants as well as in adults. In this review, we summarize recent publications
Oligodendrocyte Response to Pathophysiological Conditions Triggered by Episode of Perinatal Hypoxia-Ischemia: Role of IGF-1 Secretion by Glial Cells
TLDR
A morphometric examination of oligodendrocyte differentiation by means of the Sholl analysis showed that the treatment with low IGF-1 doses markedly improved the branching of oligdendroglial cell processes and, in this way, promoted their differentiation.
The Potential Role of Ferroptosis in Neonatal Brain Injury
TLDR
The potential relation between ferroptosis and neonatal brain injury is summarized, and according therapeutic intervention strategies are summarized.
Extracellular vesicles containing the transferrin receptor as nanocarriers of apotransferrin
TLDR
EVs are unveiled as potential nanovehicles of aTf to be delivered into the CNS parenchyma, and pave the way for further studies into their possible clinical application in the treatment of demyelinating diseases.
...
1
2
3
...

References

SHOWING 1-10 OF 60 REFERENCES
Apotransferrin-induced recovery after hypoxic/ischaemic injury on myelination
TLDR
A role for aTf as a potential inducer ofOLs in neonatal rat brain in acute demyelination caused by H/I and a contribution to the differentiation/maturation of OLs and survival/migration of SVZ progenitors after demyELination in vivo are indicated.
Minocycline attenuates hypoxia–ischemia‐induced neurological dysfunction and brain injury in the juvenile rat
TLDR
The present results show that minocycline has long‐lasting protective effects in the neonatal rat brain in terms of both hypoxia–ischemia‐induced brain injury and the associated neurological dysfunction.
Intranasal administration of insulin-like growth factor-I bypasses the blood–brain barrier and protects against focal cerebral ischemic damage
TLDR
IN IGF-I markedly reduced infarct volume and improved neurologic function following focal cerebral ischemia, demonstrating for the first time the therapeutic benefit of IN IGF-1 in rats following middle cerebral artery occlusion.
Neonatal Mice Lacking Neuronal Nitric Oxide Synthase Are Less Vulnerable to Hypoxic–Ischemic Injury
TLDR
A role for neuronally produced NO in injury after perinatal hypoxia-ischemia in the developing brain is supported, and elimination of neuronal nitric oxide synthase by targeted disruption of the nNOS gene would result in amelioration of damage seen after hypoxianesis in mice.
Intranasal Deferoxamine Provides Increased Brain Exposure and Significant Protection in Rat Ischemic Stroke
TLDR
These experiments suggest that intranasally administered DFO may be a useful treatment for stroke, and a prophylactic for patients at high risk for stroke.
NBQX Attenuates Excitotoxic Injury in Developing White Matter
TLDR
The results indicate a parallel, maturation-dependent susceptibility of immature OLs to AMPA and hypoxia/ischemia and the protective efficacy of NBQX suggests a role for glutamate receptor-mediated excitotoxic OL injury in immature white matter in vivo.
17β‐estradiol protects against hypoxic/ischemic white matter damage in the neonatal rat brain
TLDR
A potential role for estrogens in attenuation of hypoxic‐ischemic and oxidative injury to developing OLs and in the prevention of periventricular leukomalacia is suggested.
...
1
2
3
4
5
...