Intranasal administration of a PARG inhibitor profoundly decreases ischemic brain injury.

@article{Wei2007IntranasalAO,
  title={Intranasal administration of a PARG inhibitor profoundly decreases ischemic brain injury.},
  author={Guangwei Wei and Dongmin Wang and Huafei Lu and Sophie Parmentier and Qing Wang and SystemM. Panter and William H. Frey and Weihai Ying},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2007},
  volume={12},
  pages={
          4986-96
        }
}
Cumulative evidence has indicated a critical role of poly(ADP-ribose) polymerase-1 activation in ischemic brain damage. Poly(ADP-ribose) glycohydrolase (PARG) is a key enzyme in poly(ADP-ribose) catabolism. Our previous studies showed that PARG inhibitors, gallotannin (GT) and nobotanin B, can profoundly decrease oxidative cell death in vitro. Here, we tested the hypothesis that intranasal delivery of GT can decrease ischemic brain damage by inhibiting PARG. Intranasal delivery of 25 mg / kg GT… CONTINUE READING
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