Intranasal administration of IL-35 inhibits allergic responses and symptoms in mice with allergic rhinitis.

@article{Suzuki2017IntranasalAO,
  title={Intranasal administration of IL-35 inhibits allergic responses and symptoms in mice with allergic rhinitis.},
  author={Motohiko Suzuki and Makoto Yokota and Yoshihisa Nakamura and Shinya Ozaki and Shingo Murakami},
  journal={Allergology international : official journal of the Japanese Society of Allergology},
  year={2017},
  volume={66 2},
  pages={
          351-356
        }
}
BACKGROUND IL-35 was recently identified as an anti-inflammatory cytokine. We previously reported that recombinant fusion protein of murine IL-35 and human IgG1 Fc fragment (rIL-35) reduced Th2 cytokines (IL-4 and IL-5) in vitro. However, it is unclear whether IL-35 can attenuate nasal allergic responses and symptoms of allergic rhinitis in vivo. METHODS To investigate the in vivo effect of IL-35 on allergic rhinitis in mice, mice were sensitized with ovalbumin (OVA). Intranasal… CONTINUE READING
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