Intranasal absorption of oxymorphone.

  title={Intranasal absorption of oxymorphone.},
  author={M D Anower Hussain and Bruce J. Aungst},
  journal={Journal of pharmaceutical sciences},
  volume={86 8},
The nasal bioavailability of oxymorphone HCI was determined. Rats were surgically prepared to isolate the nasal cavity, into which a solution of oxymorphone was administered. A reference group of rats was administered oxymorphone HCl intravenously. Plasma oxymorphone concentrations were determined by HPLC. Nasal absorption was rapid, nasal bioavailability was 43%, and the iv and nasal elimination profiles were similar. Oxymorphone HCI appears to have the solubility, potency, and absorption… CONTINUE READING

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