Intranasal Insulin Ameliorates Experimental Diabetic Neuropathy

@inproceedings{Francis2009IntranasalIA,
  title={Intranasal Insulin Ameliorates Experimental Diabetic Neuropathy},
  author={George J Francis and J Alfredo Mart{\'i}nez and Wei Qun Liu and Thuhien Nguyen and Amit Ayer and Jared M. Fine and Douglas W Zochodne and Leah Hanson and William H. Frey and Cory C Toth},
  booktitle={Diabetes},
  year={2009}
}
OBJECTIVE We hypothesized that intranasal insulin (I-I) delivery targets the nervous system while avoiding potential adverse systemic effects when compared with subcutaneous insulin (S-I) for experimental streptozotocin-induced diabetic peripheral neuropathy (DPN). RESEARCH DESIGN AND METHODS I-I or S-I at 0.87 IU daily or placebo were delivered in separate cohorts of diabetic and nondiabetic CD1 mice during 8 months of diabetes. Radiolabeled insulin detection was used to compare delivery and… CONTINUE READING
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