Intranasal Insulin Ameliorates Experimental Diabetic Neuropathy

  title={Intranasal Insulin Ameliorates Experimental Diabetic Neuropathy},
  author={George J Francis and J Alfredo Mart{\'i}nez and Wei Qun Liu and Thuhien Nguyen and Amit Ayer and Jared M. Fine and Douglas W Zochodne and Leah Hanson and William H. Frey and Cory C Toth},
OBJECTIVE We hypothesized that intranasal insulin (I-I) delivery targets the nervous system while avoiding potential adverse systemic effects when compared with subcutaneous insulin (S-I) for experimental streptozotocin-induced diabetic peripheral neuropathy (DPN). RESEARCH DESIGN AND METHODS I-I or S-I at 0.87 IU daily or placebo were delivered in separate cohorts of diabetic and nondiabetic CD1 mice during 8 months of diabetes. Radiolabeled insulin detection was used to compare delivery and… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 48 references

Phosphatidylinositol 3-kinase and Akt effectors mediate insulin-like growth factor-I neuroprotection in dorsal root ganglia neurons.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2004
View 8 Excerpts
Highly Influenced

The renaissance of GSK3

Nature Reviews Molecular Cell Biology • 2001
View 11 Excerpts
Highly Influenced

Diabetic neuropathies and pain.

Clinics in endocrinology and metabolism • 1986
View 13 Excerpts
Highly Influenced

Glucose neurotoxicity

Nature Reviews Neuroscience • 2008
View 1 Excerpt

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