Intranasal Immune Challenge Induces Sex-Dependent Depressive-Like Behavior and Cytokine Expression in the Brain

@article{Tonelli2008IntranasalIC,
  title={Intranasal Immune Challenge Induces Sex-Dependent Depressive-Like Behavior and Cytokine Expression in the Brain},
  author={Leonardo H Tonelli and Andrew M. Holmes and Teodor T. Postolache},
  journal={Neuropsychopharmacology},
  year={2008},
  volume={33},
  pages={1038-1048}
}
The association between activation of the immune system and mood disorders has been reported by several studies. However, the mechanisms by which the immune system affects mood are only partially understood. In the present study, we detected depressive-like behavior in a rat animal model which involves the induction of inflammation in the nasal cavities by intranasal (i.n.) instillation of bacterial lipopolysaccharides (LPS). Female rats showed depressive-like behavior as evidenced by the… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 94 REFERENCES

Current estimates from the National Health Interview Survey, 1996.

  • Vital and health statistics. Series 10, Data from the National Health Survey
  • 1999
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

The HPA and immune axes in stress: the involvement of the serotonergic system.

  • European psychiatry : the journal of the Association of European Psychiatrists
  • 2005
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Cytokine-associated emotional and cognitive disturbances in humans.

  • Archives of general psychiatry
  • 2001
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL