Intranasal Delivery of pGDNF DNA Nanoparticles Provides Neuroprotection in the Rat 6-Hydroxydopamine Model of Parkinson’s Disease

@article{Aly2018IntranasalDO,
  title={Intranasal Delivery of pGDNF DNA Nanoparticles Provides Neuroprotection in the Rat 6-Hydroxydopamine Model of Parkinson’s Disease},
  author={Amirah E.-E. Aly and Brendan Trevor Harmon and Linas Padegimas and Ozge Sesenoglu-Laird and Mark W. Cooper and Barbara Lee Waszczak},
  journal={Molecular Neurobiology},
  year={2018},
  volume={56},
  pages={688-701}
}
Glial cell line-derived neurotrophic factor (GDNF) gene therapy could offer a disease-modifying treatment for Parkinson’s disease (PD). Here, we report that plasmid DNA nanoparticles (NPs) encoding human GDNF administered intranasally to rats induce transgene expression in the brain and protect dopamine neurons in a model of PD. To first test whether intranasal administration could transfect cells in the brain, rats were sacrificed 1 week after intranasal pGDNF NPs or the naked plasmid. GDNF… CONTINUE READING
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