Intranasal Delivery of RGD Motif-Containing Osteopontin Icosamer Confers Neuroprotection in the Postischemic Brain via αvβ3 Integrin Binding

@article{Jin2015IntranasalDO,
  title={Intranasal Delivery of RGD Motif-Containing Osteopontin Icosamer Confers Neuroprotection in the Postischemic Brain via αvβ3 Integrin Binding},
  author={Yin-Chuan Jin and Hahnbie Lee and Seung-Woo Kim and Il-Doo Kim and Hye Kyung Lee and Yunjin Lee and Pyung-Lim Han and Ja-Kyeong Lee},
  journal={Molecular Neurobiology},
  year={2015},
  volume={53},
  pages={5652-5663}
}
Osteopontin (OPN) is a phosphorylated glycoprotein possessing an arginine-glycine-aspartate (RGD)-motif, which binds to several cell surface integrins and mediates a wide range of cellular processes. Inductions of OPN have been reported in the postischemic brain, and the neuroprotective effects of OPN have been demonstrated in animal models of stroke. In the present study, we showed a robust neuroprotective effect of RGD-containing icosamer OPN peptide (OPNpt20) in a rat model of focal cerebral… CONTINUE READING
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