Intranasal Administration of One Alpha Gliadin Can Downregulate the Immune Response to Whole Gliadin in Mice

@article{Maurano2001IntranasalAO,
  title={Intranasal Administration of One Alpha Gliadin Can Downregulate the Immune Response to Whole Gliadin in Mice},
  author={Francesco Maurano and Rosa Anna Siciliano and Beatrice De Giulio and Diomira Luongo and Maria Fiorella Mazzeo and Riccardo Troncone and Salvatore Auricchio and Mauro Rossi},
  journal={Scandinavian Journal of Immunology},
  year={2001},
  volume={53}
}
The mucosal lesion present in coeliac disease is an immune‐mediated injury triggered by gliadin and restricted by a particular assortment of major histocompatibility complex genes. In view of this, an immunomodulatory approach that induces tolerance to this antigen appears to be a possible alternative to a strict gluten‐free diet in treating coeliac disease. We have shown that intranasal administration of multiple doses of whole gliadin is required to specifically inhibit T helper 1‐like T‐cell… Expand
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