Intramyocellular lipid content in type 2 diabetes patients compared with overweight sedentary men and highly trained endurance athletes.

@article{Loon2004IntramyocellularLC,
  title={Intramyocellular lipid content in type 2 diabetes patients compared with overweight sedentary men and highly trained endurance athletes.},
  author={Luc J. C. van Loon and Ren{\'e} Koopman and Ralph J. F. Manders and W van der Weegen and Gerrit P J van Kranenburg and Hans A. Keizer},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2004},
  volume={287 3},
  pages={E558-65}
}
Recent evidence suggests that intramyocellular lipid (IMCL) accretion is associated with obesity and the development of insulin resistance and/or type 2 diabetes. However, trained endurance athletes are markedly insulin sensitive, despite an elevated mixed muscle lipid content. In an effort to explain this metabolic paradox, we compared muscle fiber type-specific IMCL storage between populations known to have elevated IMCL deposits. Immunofluorescence microscopy was performed on muscle biopsies… CONTINUE READING