Intramyocardial injection of heart tissue-derived extracellular matrix improves postinfarction cardiac function in rats.

@article{Dai2013IntramyocardialIO,
  title={Intramyocardial injection of heart tissue-derived extracellular matrix improves postinfarction cardiac function in rats.},
  author={Wangde Dai and Paul Gerczuk and Yuanyuan Zhang and Leona C Smith and Oleg V Kopyov and Gregory Louis Kay and Aarne J Jyrala and Robert A. Kloner},
  journal={Journal of cardiovascular pharmacology and therapeutics},
  year={2013},
  volume={18 3},
  pages={270-9}
}
AIMS We determined whether implantation of heart tissue-derived decellularized matrix, which contains native biochemical and structural matrix composition, could thicken the infarcted left ventricular (LV) wall and improve LV function in a rat myocardial infarction model. METHODS AND RESULTS Myocardial infarction was induced by left coronary ligation in Fischer rats. One week later, saline (75 μL, n = 17) or matrix (75 μL, n = 19) was directly injected into the infarcted area. At 6 weeks… CONTINUE READING
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