Intramuscular injection of tumor necrosis factor-alpha induces muscle hyperalgesia in rats.

@article{Schfers2003IntramuscularIO,
  title={Intramuscular injection of tumor necrosis factor-alpha induces muscle hyperalgesia in rats.},
  author={Maria Sch{\"a}fers and Linda S. Sorkin and Claudia Sommer},
  journal={Pain},
  year={2003},
  volume={104 3},
  pages={579-88}
}
The role of proinflammatory cytokines in neuropathic and inflammatory pain is well established. Recent studies suggest that cytokines such as tumor necrosis factor-alpha (TNF) may also be involved in the development of muscle pain. To investigate the pathophysiology of intramuscular TNF, exogenous TNF (0.1-10 microg), formalin (9%) or vehicle was injected into the gastrocnemius or biceps brachii muscles of rats. To quantify muscle hyperalgesia, changes in forelimb grip force or withdrawal… CONTINUE READING
52 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 52 extracted citations

Similar Papers

Loading similar papers…