Intramuscular gene transfer of interleukin-10 cDNA reduces atherosclerosis in apolipoprotein E-knockout mice.

@article{Namiki2004IntramuscularGT,
  title={Intramuscular gene transfer of interleukin-10 cDNA reduces atherosclerosis in apolipoprotein E-knockout mice.},
  author={M. Namiki and S. Kawashima and T. Yamashita and M. Ozaki and T. Sakoda and N. Inoue and K. Hirata and R. Morishita and Y. Kaneda and M. Yokoyama},
  journal={Atherosclerosis},
  year={2004},
  volume={172 1},
  pages={
          21-9
        }
}
Atherosclerosis has a close relationship to inflammation, particularly T helper type 1 lymphocyte (Th1) response. Interleukin-10 (IL-10), is thought to suppress Th1 response. To target therapeutic strategy for atherosclerosis, we tested whether IL-10 gene transfer suppresses atherosclerosis in apolipoprotein E-knockout (apoE-KO) mice. Four-week-old apoE-KO mice were divided into two groups and either murine IL-10 cDNA plasmid or empty control vector was transferred to the femoral muscle with… Expand
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