Intramuscular gene transfer of fibroblast growth factor-1 using improved pCOR plasmid design stimulates collateral formation in a rabbit ischemic hindlimb model

@article{Witzenbichler2005IntramuscularGT,
  title={Intramuscular gene transfer of fibroblast growth factor-1 using improved pCOR plasmid design stimulates collateral formation in a rabbit ischemic hindlimb model},
  author={Bernhard Witzenbichler and Abderrahim Mahfoudi and Fabienne Soubrier and Aude Le Roux and Didier Branellec and Heinz-Peter Schultheiss and Jeffrey M. Isner},
  journal={Journal of Molecular Medicine},
  year={2005},
  volume={84},
  pages={491-502}
}
Fibroblast growth factor 1 (FGF1) is an angiogenic factor known to play a role in the growth of arteries. The purpose of this study was to evaluate the usefulness of direct intramuscular injection of an optimized expression plasmid encoding FGF1 to augment collateral formation and tissue perfusion in a rabbit ischemic hindlimb model. Truncated FGF1 fused to the human fibroblast interferon (FIN) signal peptide was expressed from a newly designed plasmid backbone with an improved safety profile… CONTINUE READING