Intramuscular distribution of botulinum toxin--visualized by MRI.

  title={Intramuscular distribution of botulinum toxin--visualized by MRI.},
  author={Kirsten Elwischger and Gregor Kasprian and Michael Weber and Martin Meyerspeer and Christa Linder and Eduard Auff and Daniela Prayer and Thomas Sycha and Gottfried Kranz},
  journal={Journal of the neurological sciences},
  volume={344 1-2},
OBJECTIVE A precise knowledge of the spread of botulinum toxin (BoNT) in muscle tissue is required to efficiently access endplate zones and increase BoNT's therapeutic efficacy. Here, we aimed to understand the spatiotemporal dynamics of BoNT distribution in skeletal muscle and its modulating factors, such as injected volume and exercise after injection. METHODS To visualize distribution in muscle tissue, sagittal, dynamic, balanced fast field echo (BFFE) MRI imaging was performed during… CONTINUE READING


Publications citing this paper.

Similar Papers

Loading similar papers…