Intramuscular adipose is derived from a non-Pax3 lineage and required for efficient regeneration of skeletal muscles.

@article{Liu2012IntramuscularAI,
  title={Intramuscular adipose is derived from a non-Pax3 lineage and required for efficient regeneration of skeletal muscles.},
  author={Weiyi Liu and Yaqin Liu and Xinsheng Lai and Shihuan Kuang},
  journal={Developmental biology},
  year={2012},
  volume={361 1},
  pages={27-38}
}
Ectopic accumulation of adipose in the skeletal muscle is associated with muscle wasting, insulin resistance and diabetes. However, the developmental origin of postnatal intramuscular adipose and its interaction with muscle tissue are unclear. We report here that compared to the fast EDL muscles, slow SOL muscles are more enriched with adipogenic progenitors and have higher propensity to form adipose. Using Cre/LoxP mediated lineage tracing in mice, we show that intramuscular adipose in both… CONTINUE READING
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