Intramolecular titanium-mediated aminocyclopropanation of terminal alkenes: easy access to various substituted azabicyclo[n.1.0]alkanes.

Abstract

[reaction: see text] A variety of substituted azabicyclo[n.1.0]alkanes were synthesized by intramolecular titanium-mediated cyclopropanation of N-benzyl-N-(2-alkylalk-3-enyl)formamides and N-benzyl-N-alkadienylformamides. N-Benzylpyrroline upon treatment with Grignard reagents undergoes a titanium-mediated carbomagnesiation to yield N-benzyl-N-(2-alkylbut-3… (More)

Topics

  • Presentations referencing similar topics